Generalized Urticaria as Acute Transfusion Reaction in Children: A Case Report
Main Article Content
Keywords
Beta-thalassemia, generalized urticaria, packed red cell
Abstract
Introduction: Transfusions in children and neonates are less common than in adults. The risk of transfusion reactions in children is two times greater than in adults. The most common transfusion reaction is an allergic reaction. This paper aims to discuss a case of generalized urticarial responses in pediatric patients who received PRC transfusions.
Case Description: A 12-year-old boy, treated with beta-thalassemia since 5 years ago and gets regular transfusions. After receiving the second bag of PRC transfusion with a volume of 50 mL, the patient complained of itching and redness all over the body. The complaints were getting worse, and bumps appeared all over the body 15 minutes after the transfusion was stopped. Laboratory test results support thalassemia and several complications of repeated transfusions, such as increased ferritin levels and decreased liver function. The results of the pretransfusion test before and after the transfusion were B-positive blood type and compatible crossmatch results. The patient recovered after being treated as a moderate-severe transfusion reaction.
Conclusion: Allergic reaction is an acute transfusion reaction involving an immunological response. Fast responses to acute transfusion reactions are very helpful in improving patient conditions.
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